Developmental methoxychlor exposure affects multiple reproductive parameters and ovarian folliculogenesis and gene expression in adult rats
نویسندگان
چکیده
منابع مشابه
Morphine and kisspeptin influences on 5-α reductase and aromatase gene expression in adult male rats
Objective(s): Kisspeptin and opioids are important factors for controlling GnRH/LH secretion. In present study, influences of kisspeptin or morphine were investigated on 5α- reductase or aromatase (CYP19) genes expression in the hypothalamus, testis and liver. It aimed to investigate whether kisspeptin pathway may control morphine effects on plasma concentration of tes...
متن کاملEffect of Ehretia Microphylla Lamk on Stimulation of Reproductive Function and Ovarian Folliculogenesis in Rats
This study has been undertaken to investigate the effect of Ehretia microphylla L._ on folliculogenesis, relative ovary and uterus weight and the number of ovarian surface follicles in female Wistar albino rats. The study consisted of 24 female wistar rats that were divided into four groups. Group-I 0.5 ml distilled water, Group II, III and IV were orally administered with powdered form of E. m...
متن کاملP-78: Effects of Endurance Exercise on Reproductive and Oxidative Parameters in Adult Male Rats
Background: In order to investigate the effects of endurance exercise on male reproductive function in relation to oxidative stress. Materials and Methods: a total of 20 male wistar rats were randomly divided into the following groups: control group (n=10) and exercised group (n=10). A protocol of 60 minutes exercise per day, five days per week was followed for 8 weeks. At the end of experiment...
متن کاملFetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes.
Exposure to endocrine-disrupting chemicals during development could alter the epigenetic programming of the genome and result in adult-onset disease. Methoxychlor (MXC) and its metabolites possess estrogenic, antiestrogenic, and antiandrogenic activities. Previous studies showed that fetal/neonatal exposure to MXC caused adult ovarian dysfunction due to altered expression of key ovarian genes i...
متن کاملNickel Nanoparticles Exposure and Reproductive Toxicity in Healthy Adult Rats
Nickel is associated with reproductive toxicity. However, the reproductive toxicity of nickel nanoparticles (Ni NPs) is unclear. Our goal was to determine the association between nickel nanoparticle exposure and reproductive toxicity. According to the one-generation reproductive toxicity standard, rats were exposed to nickel nanoparticles by gavage and we selected indicators including sex hormo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 2008
ISSN: 0041-008X
DOI: 10.1016/j.taap.2008.09.010